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The vascular territory affected will determine the exact symptoms and clinical behavior of the lesion:

The symptoms often evolve over hours and may worsen or improve, depending on the fate of the ischemic penumbra. Clinical presentationĪn ischemic stroke typically presents with rapid onset neurological deficit, which is determined by the area of the brain that is involved. Risk factors for ischemic stroke largely mirror the risk factors for atherosclerosis and include age, gender, family history, smoking, hypertension, hypercholesterolemia, and diabetes mellitus. Stroke is the second most common cause of morbidity worldwide (after myocardial infarction) and is the leading cause of acquired disability 2. The evidence of infarction may be based on imaging, pathology, and/or persistent neurologic symptoms, with other causes excluded. If there is imaging or pathologic evidence of an infarct but no attributable clinical symptoms, then it is called a "silent CNS infarction." Epidemiology

The term " stroke" is a clinical determination, whereas "infarction" is fundamentally a pathologic term 1. Bridging these terms, ischemic stroke is the subtype of stroke that requires both a clinical neurologic deficit and evidence of CNS infarction (cell death attributable to ischemia).